The Clinical Meaning of Walking Speed as Measured by the Timed 25-Foot Walk...
ImportanceWalking impairment, a common clinical manifestation of multiple sclerosis (MS), is often measured in clinical practice and clinical trials using the Timed 25-Foot Walk (T25-FW).ObjectiveTo...
View ArticleSeroprevalence of Aquaporin-4–IgG in a Northern California Population...
ImportanceUsing an aquaporin-4 (AQP4) M1-isoform–specific enzyme-linked immunosorbent assay (ELISA) and a fixed transfected cell-based assay (CBA), we tested AQP4-IgG in a northern California...
View ArticleMycophenolate Mofetil in the Treatment of Neuromyelitis Optica Spectrum Disorder
ImportanceNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system. Recently, various immunosuppressant medications were introduced as...
View ArticleMycophenolate Mofetil to Treat Neuromyelitis Optica Is It Time for a...
Should clinical trials of disease-modifying therapies be conducted for neuromyelitis optica (NMO)? If so, how should these trials be designed and which therapy tested? Because of its relative scarcity...
View ArticleThe Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells...
ImportanceThis study describes what is, to our knowledge, the previously unknown effect of glatiramer acetate therapy on B cells in patients with relapsing-remitting multiple sclerosis (MS).ObjectiveTo...
View ArticleAutologous Stem Cell Transplantation for Stiff Person Syndrome Two Cases From...
ImportanceStiff person syndrome (SPS) is a rare neurological disease causing significant functional disability for patients and presenting a therapeutic challenge for clinicians. Autologous...
View ArticleImpaired Cerebrovascular Reactivity in Multiple Sclerosis
ImportanceCerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral arterioles for a vasomotor stimulus for maintaining a spontaneous and instant increase of...
View ArticleShort Myelitis Lesions in Aquaporin-4-IgG–Positive Neuromyelitis Optica...
ImportanceShort transverse myelitis (STM; <3 vertebral segments) is considered noncharacteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs). Nonappreciation of the potential for STM...
View ArticleSevere Cognitive Impairment Associated With Intrathecal Antibodies to the NR1...
ImportanceSome patients with multiple sclerosis (MS) can either present with or develop severe cognitive impairment during the course of their disease. However, the mechanisms underlying severe...
View ArticleThe Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells...
ImportanceThis study describes what is, to our knowledge, the previously unknown effect of glatiramer acetate therapy on B cells in patients with relapsing-remitting multiple sclerosis (MS).ObjectiveTo...
View ArticleMycophenolate Mofetil in the Treatment of Neuromyelitis Optica Spectrum Disorder
ImportanceNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disorder of the central nervous system. Recently, various immunosuppressant medications were introduced as...
View ArticleMycophenolate Mofetil to Treat Neuromyelitis Optica Is It Time for a...
Should clinical trials of disease-modifying therapies be conducted for neuromyelitis optica (NMO)? If so, how should these trials be designed and which therapy tested? Because of its relative scarcity...
View ArticleThe Clinical Meaning of Walking Speed as Measured by the Timed 25-Foot Walk...
ImportanceWalking impairment, a common clinical manifestation of multiple sclerosis (MS), is often measured in clinical practice and clinical trials using the Timed 25-Foot Walk (T25-FW).ObjectiveTo...
View ArticleSeroprevalence of Aquaporin-4–IgG in a Northern California Population...
ImportanceUsing an aquaporin-4 (AQP4) M1-isoform–specific enzyme-linked immunosorbent assay (ELISA) and a fixed transfected cell-based assay (CBA), we tested AQP4-IgG in a northern California...
View ArticleAssociation of Cerebrospinal Fluid Levels of Lateral Olfactory Tract Usher...
ImportanceAlthough multiple sclerosis (MS) is generally considered an autoimmune demyelinating disorder of the central nervous system, axonal degeneration through Nogo receptor-1 signaling was recently...
View ArticleInvestigations on CXCL13 in Anti– N -Methyl- D -Aspartate Receptor...
ImportanceAnti–N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe but treatable autoimmune encephalitis affecting mainly young adults and children. The lack of suitable biomarkers of...
View ArticleHigh-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell...
ImportanceMost patients with relapsing-remitting (RR) multiple sclerosis (MS) who receive approved disease-modifying therapies experience breakthrough disease and accumulate neurologic disability....
View ArticleMoving Targets for Hematopoietic Stem Cell Transplantation for Multiple...
Stem cell transplant for multiple sclerosis (MS) has been a subject of great interest to scientists, physicians, and patients. The status of stem cell therapy is a common question posed by patients at...
View ArticleShort Myelitis Lesions in Aquaporin-4-IgG–Positive Neuromyelitis Optica...
ImportanceShort transverse myelitis (STM; <3 vertebral segments) is considered noncharacteristic of neuromyelitis optica (NMO) spectrum disorders (NMOSDs). Nonappreciation of the potential for STM...
View ArticleSevere Cognitive Impairment Associated With Intrathecal Antibodies to the NR1...
ImportanceSome patients with multiple sclerosis (MS) can either present with or develop severe cognitive impairment during the course of their disease. However, the mechanisms underlying severe...
View Article