Population-Level Evidence for an Autoimmune Etiology of Epilepsy
ImportanceEpilepsy is a debilitating condition, often with neither a known etiology nor an effective treatment. Autoimmune mechanisms have been increasingly identified.ObjectiveTo conduct a...
View ArticleParaneoplastic Neuromyelitis Optica Spectrum Disorder Associated With...
ImportanceReports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic...
View ArticleSwitching From Natalizumab to Fingolimod in Multiple Sclerosis A French...
ImportanceThe safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge.ObjectiveTo collect...
View ArticleCentral Nervous System Manifestation of IgG4-Related Disease
ImportanceIgG4-related disease (IgG4-RD) is characterized by an inflammatory reaction rich in IgG4-positive plasma cells. Head and brain involvement is rare in IgG4-RD, and brain parenchyma involvement...
View ArticleImmunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis In...
ImportanceCerebrospinal fluid (CSF) is the compartment in closest proximity to the central nervous system (CNS) parenchyma and might reflect immune pathology in inflammatory CNS disorders like multiple...
View ArticlePopulation-Level Evidence for an Autoimmune Etiology of Epilepsy
ImportanceEpilepsy is a debilitating condition, often with neither a known etiology nor an effective treatment. Autoimmune mechanisms have been increasingly identified.ObjectiveTo conduct a...
View ArticleTransverse Myelitis Associated With an Itchy Rash and HyperCKemia...
ImportanceNeuromyelitis optica is associated with severe neurodisability if not recognized and treated promptly. Several autoimmune disorders are associated with this condition and may vary in their...
View ArticleTransverse Myelitis Plus Syndrome and Acute Disseminated Encephalomyelitis...
ImportanceClassically, transverse myelitis and acute disseminated encephalomyelitis are considered central nervous system demyelinating conditions. In both conditions, the spinal cord is involved to...
View ArticleComparison of Plasmapheresis and Intravenous Immunoglobulin as Maintenance...
ImportanceJuvenile myasthenia gravis (MG) is a relatively rare autoimmune disorder. The comparative efficacy of plasmapheresis (PLEX) vs immunoglobulin as maintenance therapy is unclear for this...
View ArticleMagnetic Resonance Spectroscopy Markers of Disease Progression in Multiple...
ImportancePredicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple sclerosis pathologic damage typically includes demyelination,...
View ArticleMagnetic Resonance Spectroscopy A Possible In Vivo Marker of Disease...
Multiple sclerosis (MS) is a common, chronic neurological disease with a highly variable prognosis and clinical course. There is a pressing need for reliable predictors of future disease course not...
View ArticleInadequacy of Clinical Trial Designs and Data to Control for the Confounding...
Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by a complex mix of genetics and gene-environment interactions. As compared with white Americans, African Americans are...
View ArticleAutoimmune Aquaporin-4 Myopathy in Neuromyelitis Optica Spectrum
ImportanceDocumentation of muscle pathology compatible with targeting of sarcolemmal aquaporin-4 (AQP4) by complement-activating IgG implies involvement of organs beyond the central nervous system in...
View ArticleTreatment of Relapsing-Remitting Multiple Sclerosis After 24 Doses of...
ImportanceThe evaluation of therapeutic choices is needed after 24 doses of natalizumab in patients with multiple sclerosis (MS).ObjectiveTo evaluate the effect of therapeutic choices on the mean...
View ArticleDoes Natalizumab Therapy Benefit Patients With Multiple Sclerosis?
Does natalizumab therapy benefit patients with multiple sclerosis (MS)? The obvious answer is yes. Natalizumab was approved for patients with relapsing forms of MS by regulatory agencies based on the...
View ArticleMagnetic Resonance Spectroscopy Markers of Disease Progression in Multiple...
ImportancePredicting disease evolution is becoming essential for optimizing treatment decision making in multiple sclerosis (MS). Multiple sclerosis pathologic damage typically includes demyelination,...
View ArticleMagnetic Resonance Spectroscopy A Possible In Vivo Marker of Disease...
Multiple sclerosis (MS) is a common, chronic neurological disease with a highly variable prognosis and clinical course. There is a pressing need for reliable predictors of future disease course not...
View ArticleImmunophenotyping of Cerebrospinal Fluid Cells in Multiple Sclerosis In...
ImportanceCerebrospinal fluid (CSF) is the compartment in closest proximity to the central nervous system (CNS) parenchyma and might reflect immune pathology in inflammatory CNS disorders like multiple...
View ArticleImpaired Cerebrovascular Reactivity in Multiple Sclerosis
ImportanceCerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral arterioles for a vasomotor stimulus for maintaining a spontaneous and instant increase of...
View ArticleAutologous Stem Cell Transplantation for Stiff Person Syndrome Two Cases From...
ImportanceStiff person syndrome (SPS) is a rare neurological disease causing significant functional disability for patients and presenting a therapeutic challenge for clinicians. Autologous...
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