Transdermal Application of Myelin Peptides in Multiple Sclerosis Treatment...
ImportanceDemonstration of efficacious antigen-specific therapy in multiple sclerosis.ObjectiveTo assess the safety and efficacy of transdermally applied myelin peptides in patients with...
View ArticleThe Road Not Taken Antigen-Specific Therapy and Neuroinflammatory Disease The...
Ninety-seven years ago, Robert Frost wrote The Road Not Taken, beginning famously, “Two roads diverged in a yellow wood, And sorry I could not travel both.” In 2013, the pharmaceutical industry has...
View ArticleAquaporin 4 Expression and Tissue Susceptibility to Neuromyelitis Optica AQP4...
ImportanceTo understand the predilection for optic nerve and spinal cord pathologic changes in neuromyelitis optica (NMO).ObjectiveTo evaluate tissue-specific expression (RNA and protein) and...
View ArticleNeuronal Surface and Glutamic Acid Decarboxylase Autoantibodies in...
ImportanceHigh titers of autoantibodies to glutamic acid decarboxylase (GAD) are well documented in association with stiff person syndrome (SPS). Glutamic acid decarboxylase is the rate-limiting enzyme...
View ArticleA 5-Year Follow-up of Rituximab Treatment in Patients With Neuromyelitis...
ImportanceA previous 2-year analysis of repeated rituximab treatment in patients with neuromyelitis optica (NMO) revealed significant improvements in relapse rates and disability. We report the...
View ArticleIndividualized Rituximab Treatment for Neuromyelitis Optica Spectrum...
Neuromyelitis optica (NMO) spectrum disorders (NMOSDs) are inflammatory disorders of the central nervous system (CNS) characterized by attacks of optic neuritis or myelitis or both. The NMOSDs are the...
View ArticleTherapeutic Decisions in Multiple Sclerosis Moving Beyond Efficacy...
Several innovative disease-modifying treatments (DMTs) for relapsing-remitting multiple sclerosis have been licensed recently or are in late-stage development. The molecular targets of several of these...
View ArticleLongitudinally Extensive Transverse Myelitis With and Without Aquaporin 4...
ImportanceAquaporin 4 antibody (AQP4-Ab)–negative patients with longitudinally extensive transverse myelitis (LETM) behave differently from those with AQP4-Ab. Aquaporin 4 antibody–negative...
View ArticleAquaporin 4 IgG Serostatus and Outcome in Recurrent Longitudinally Extensive...
ImportanceStudies focused on recurrent longitudinally extensive transverse myelitis (rLETM) are lacking.ObjectivesTo determine the aquaporin 4 (AQP4) IgG detection rate using recombinant human...
View ArticleMultiple Sclerosis Disease Progression and Paradichlorobenzene A Tale of...
ImportanceEnvironmental factors are thought to be critical in the initiation and perpetuation of multiple sclerosis disease activity.ObservationsWe describe the case of a woman in her late 30s with a...
View ArticleDisease Activity Free Status A New End Point for a New Era in Multiple...
Since the introduction of interferon beta-1b in 1993, the number of disease-modifying therapies for multiple sclerosis (MS) has grown at a remarkable pace. Currently there are 10 treatments approved by...
View ArticleAlcohol as a Modifiable Lifestyle Factor Affecting Multiple Sclerosis Risk
ImportanceAlcohol consumption may be a modifiable lifestyle factor that affects the risk of developing multiple sclerosis (MS). Results of previous studies have been inconsistent.ObjectiveTo...
View ArticleNeuromyelitis Optica Spectrum Disorders With Aquaporin-4 and...
ImportanceMost patients with neuromyelitis optica (NMO) and many with NMO spectrum disorder have autoantibodies against aquaporin-4 (AQP4-Abs), but recently, myelin-oligodendrocyte glycoprotein...
View ArticleDoes Aquaporin-4–Seronegative Neuromyelitis Optica Exist?
With the improvement in anti–aquaporin-4 (AQP4) assay sensitivity to near 90%, the concept of seronegative neuromyelitis optica (NMO) is being challenged. The widely accepted criteria for NMO proposed...
View ArticleComparison of Relapse and Treatment Failure Rates Among Patients With...
ImportanceNeuromyelitis optica (NMO) is an inflammatory disease of the optic nerves and spinal cord that leads to blindness and paralysis. Effective immunosuppression is the standard of care for...
View ArticleMultiple Sclerosis Disease Progression and Paradichlorobenzene A Tale of...
ImportanceEnvironmental factors are thought to be critical in the initiation and perpetuation of multiple sclerosis disease activity.ObservationsWe describe the case of a woman in her late 30s with a...
View ArticleSwitching From Natalizumab to Fingolimod in Multiple Sclerosis A French...
ImportanceThe safety and efficacy of switching from natalizumab to fingolimod have not yet been evaluated in a large cohort of patients with multiple sclerosis (MS) to our knowledge.ObjectiveTo collect...
View ArticleComparison of Plasmapheresis and Intravenous Immunoglobulin as Maintenance...
ImportanceJuvenile myasthenia gravis (MG) is a relatively rare autoimmune disorder. The comparative efficacy of plasmapheresis (PLEX) vs immunoglobulin as maintenance therapy is unclear for this...
View ArticleTransverse Myelitis Associated With an Itchy Rash and HyperCkemia...
ImportanceNeuromyelitis optica is associated with severe neurodisability if not recognized and treated promptly. Several autoimmune disorders are associated with this condition and may vary in their...
View ArticleTransverse Myelitis Plus Syndrome and Acute Disseminated Encephalomyelitis...
ImportanceClassically, transverse myelitis and acute disseminated encephalomyelitis are considered central nervous system demyelinating conditions. In both conditions, the spinal cord is involved to...
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