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Channel: JAMA Neurology: Autoimmune Diseases Topic Collection
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Comparison of Switch to Fingolimod or Interferon Beta/Glatiramer Acetate in...

ImportanceAfter multiple sclerosis (MS) relapse while a patient is receiving an injectable disease-modifying drug, many physicians advocate therapy switch, but the relative effectiveness of different...

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Treatment Decisions for Patients With Active Multiple Sclerosis

In the complex scenario of current multiple sclerosis (MS) treatment options, it is becoming imperative for clinicians to have the instruments to make prompt treatment decisions for patients who have a...

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Transglutaminase 6 Antibodies in the Serum of Patients With ALS

This case-control study suggests that an amyotrophic lateral sclerosis syndrome might be associated with autoimmunity and gluten sensitivity.

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Antibodies to Clustered Acetylcholine Receptors and Myasthenia Gravis

This cohort study determines the diagnostic usefulness of cell-based assays in the diagnosis of myasthenia gravis and compares the clinical features of patients with antibodies only to clustered...

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Unraveling the Enigma of Seronegative Myasthenia Gravis

Myasthenia gravis (MG) is the prototypic autoimmune neurological disorder. Weakness and muscle fatigue in MG result from an autoimmune attack on the neuromuscular junction, which causes a failure of...

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Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase

This case series study describes the clinical and immunological features of patients with paraneoplastic neurological syndromes and glutamic acid decarboxylase antibodies.

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Features and Outcomes of Necrotizing Autoimmune Myopathy

This medical record review study of patients with necrotizing autoimmune myopathy describes characteristics of the disease and determines clinical outcome predictors.

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The Clinical Spectrum of Necrotizing Autoimmune Myopathy

Necrotizing autoimmune myopathy (NAM) is a recently defined subcategory of the acquired idiopathic myopathies, characterized clinically by the subacute onset of proximal weakness, elevated creatine...

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Encephalitis Associated With Antibodies Against the AMPA Receptor

This case series describes 7 patients with encephalitis with antibodies against the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor and provides a review of the literature on this disease...

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Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase

This case series study describes the clinical and immunological features of patients with paraneoplastic neurological syndromes and glutamic acid decarboxylase antibodies.

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Features and Outcomes of Necrotizing Autoimmune Myopathy

This medical record review study of patients with necrotizing autoimmune myopathy describes characteristics of the disease and determines clinical outcome predictors.

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The Clinical Spectrum of Necrotizing Autoimmune Myopathy

Necrotizing autoimmune myopathy (NAM) is a recently defined subcategory of the acquired idiopathic myopathies, characterized clinically by the subacute onset of proximal weakness, elevated creatine...

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Rituximab Therapy in Neuromyelitis Optica

Neuromyelitis optica (NMO) spectrum disorders represent an evolving group of central nervous system–inflammatory autoimmune demyelinating diseases unified by a pathogenic autoantibody specific for the...

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Autoimmune Cerebellar Ataxia Accompanying Neural Antibodies in Adults

This cohort study reports the treatment and outcome experience of a single clinic in a population of adults with autoimmune cerebellar ataxia.

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Novel Variant of Miller Fisher Syndrome

This case report describes a 43-year-old woman who presented to an acute medical team with a 3-day history of worsening diplopia.

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Multiple Sclerosis Disease-Modifying Therapy Effects

This review examines the effects of multiple sclerosis disease-modifying therapies on B-cell immunity.

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Effects of Metformin and Pioglitazone in Metabolic Syndrome and MS

This cohort study evaluates the effects of metformin and pioglitazone on immune regulation in patients with multiple sclerosis and metabolic syndrome and evaluates potential mechanisms underlying this...

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Stiff-Person Spectrum Disorder Investigations

This case-series study reports the clinical and immunologic findings in a cohort of patients with stiff-person spectrum disorder, including stiff-person syndrome, stiff-limb syndrome, or stiff-person...

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Hematopoietic Stem Cell Transplantation–Treated Myasthenia Gravis

This study reports 7 cases of severe myasthenia gravis treated with autologous hematopoietic stem cell transplant in which consistent, durable, symptom-free, and treatment-free remission was achieved.

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Alemtuzumab and Multiple Sclerosis

Alemtuzumab is a humanized monoclonal antibody that binds to CD52, a surface molecule expressed by many types of immune cells, including T lymphocytes, B lymphocytes, monocytes, macrophages, and...

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